Neovite
Multi-functional food for health and performance

Multi-functional food for health and performance

neovite is dairy protein from milk taken in the first 48 hours after calving and includes colostrum.
colostrum is an exceptional natural food prized by many cultures for thousands of years.

in brief

Colostrum Gut Study -read full paper

Neovite reduces the increase in gut permeability caused by intense exercise
Am Journal Physiology 01/03/2010 read more
 

Prof Ray Playford, gastroenterologist,

Queen Mary's College, a video interview
Colostrum UK Ltd 02/12/2006 read more
 

Gut research science review

Prof. Ray Playford et al.
Review of colostrum in gastroenterology

Clinical Nutrition 05/07/2000 read more
 




Digestive efficiency



This information is not generally allowed to viewed online as the public description of the health benefits of foodstuffs is restricted under EU regulations 1924/2006.


Published science in peer-reviewed journals may be permitted, so here is the abstract from our published research


The American Journal of Physiology - Gastro-intestinal and Liver Physiology

Published online before print December 2010, in print March 2011 vol. 300 no. 3 G477-G484


"bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes"


1. Tania Marchbank (1),
2. Glen Davison (2),
3. Jemma R. Oakes (2),
4. Mohammad A. Ghateib (3),
5. Michael Patterson (3),
6. Mary Pat Moyer (4),
7. Raymond J. Playford (1)


+ Author Affiliations

(1) Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine, Queen Mary University of London, London;

(2) Department of Sport and Exercise Science, Aberystwyth University, Aberystwyth;

(3) Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom;

(4) INCELL Corporation, San Antonio, Texas


Heavy exercise causes gut symptoms and, in extreme cases, “heat stroke” partially due to increased intestinal permeability of luminal toxins.


We examined bovine colostrum, a natural source of growth factors, as a potential moderator of such effects. Twelve volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum/placebo) prior to standardized exercise. Gut permeability utilized 5 h urinary lactulose-to-rhamnose ratios.


In vitro studies (T84, HT29, NCM460 human colon cell lines) examined colostrum effects on temperature-induced apoptosis (active caspase-3 and 9, Baxá, Bcl-2), heat shock protein 70 (HSP70) expression and epithelial electrical resistance.


In both study arms, exercise increased blood lactate, heart rate, core temperature (mean 1.4°C rise) by similar amounts.


Gut hormone profiles were similar in both arms although GLP-1 levels rose following exercise in the placebo but not the colostrum arm (P = 0.026). Intestinal permeability in the placebo arm increased 2.5-fold following exercise (0.38 ± 0.012 baseline, to 0.92 ± 0.014, P < 0.01), whereas colostrum truncated rise by 80% (0.38 ± 0.012 baseline to 0.49 ± 0.017) following exercise.


In vitro apoptosis increased by 47–65% in response to increasing temperature by 2°C. This effect was truncated by 60% if colostrum was present (all P < 0.01).


Similar results were obtained examining epithelial resistance (colostrum truncated temperature-induced fall in resistance by 64%, P < 0.01).


Colostrum increased HSP70 expression at both 37 and 39°C (P < 0.001) and was truncated by addition of an EGF receptor-neutralizing antibody. Temperature-induced increase in Baxá and reduction in Bcl-2 was partially reversed by presence of colostrum.


Colostrum may have value in enhancing athletic performance and preventing heat stroke




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