Radio 4 'On Your Farm'
Short radio documentary on colostrum by the Farming Today team.
My name is John Rolfs and I’m 53 years old. For the last 20 years...
Gut research science review
Prof. Ray Playford et al.
Review of colostrum in gastroenterology
Athletes increase performance
Research study of athletes in training using a colostrum supplement...
neovite has proved to be capable of binding to and therefore inhibits colonisation by: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus mutans, Escherichia coli, Salmonella enteritidis, Klebsiella pneumoniae, Helicobacter pylori, Yersinia enterocolitica, Bacillus cereus, Proponibacterium acnes, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus agalactiae, Escherichia coli 0157:H7, Salmonella typhimurium, Haemophilus influenzae, Listeria monocytogenes, Campylobacter jejuni, Candida albicans.
Allan Walker, MD, reported in 1975, that antigen absorption through the intestinal wall was linked to several clinical diseases. Dr. Walker suggested that preventing this antigen absorption would be due to mothers breast feeding their babies for at least the first three months of life. Thanks to Dr. Walker, it is now a well-known fact that the immune factors passed from the first mother's milk (colostrum) to the child, will protect the infant from invading micro-organisms.
Formula-fed infants are more prone to a variety of infections. One reason for this may be that infant formula from cows milk lacks the active antibodies and other immune components naturally present in human breast milk. More than 15 articles and abstracts (from 1979 to the present) have been published discussing use of specific immunoglobulin products in the prevention and treatment of two major causes of infantile diarrhea, E. coli and rotavirus. Use of these specific immunoglobulin products in multiple clinical studies successfully treated or prevented infantile diarrhea in most, but not all studies. Where positive, they had the effect of reducing or preventing colonisation, disease and mortality.
Streptococcus mutans is the principal agent responsible for the formation of dental caries (cavities). Recent studies have documented maternal-child transmission as the primary mode of infection; children colonised later in life appear to develop fewer cavities. Several studies have documented use of a mouth rinse containing cow antibodies to reduce Streptococcus mutans colonisation in adult volunteers. In the treatment groups, fewer and smaller colonies of Streptococcus mutans were recovered, which suggests that the antibodies interfered with the metabolic growth of existing colonies. Inhibition of glucosyltransferase, involved in adherence, by immunoglobulins has been reported as well. Specific antibodies can also be directed at the organisms in gum disease.
This yeast is a normal resident of the mouth and intestinal tract. In immunocompromised patients or those on certain antibiotics, Candida overgrowth can cause severe problems. The local infection in the mouth can rapidly become a systemic infection, resulting in high mortality. In a recent trial in bone marrow transplant patients with initial high colony counts in saliva samples, prophylactic administration of anti-Candida albicans dairy antibodies as a mouthrinse, appeared to reduce colonisation in a majority of patients. Thus, antibodies from colostrum have demonstrated activity against Candida albicans.
Diarrhea and Food Poisoning
Colonisation by gut pathogens appears to be reduced by dietary antibodies. Shigella is one of the organisms that commonly cause traveler's diarrhea. In normal adult volunteers fed live Shigella flexneri bacteria, dairy immunoglobulins provided complete protection from illness and a marked reduction in diarrheal symptoms. Shigella can be particularly virulent, because as few as 10 live organisms can cause major intestinal diarrheal symptoms.
Cryptosporidium parvum is a protozoal parasite for which no approved efficacious treatment is available. Cryptosporidium parvum can cause outbreaks of food poisoning. Specific dairy immunoglobulins have been reported to improve diarrheal symptoms and reduce oocyst shedding in individual case studies and in clinical trials in severely immunocompromised (AIDS) adult and pediatric patients. In most cases, patients had suffered debilitating diarrhea for months to years and had failed all other available experimental therapeutics.
Long before medical science realised that stomach ulcers could be caused by bacterial infection, milk and other dairy products were promoted for the relief of ulcer symptoms. It now appears that dairy colostral antibodies directed against Helicobacter pylori may actively prevent adherence of the organism and inhibit colonisation. Additionally, other bactericidal agents may be present in dairy colostrum and milk preparations that impact H. pylori. In several studies in children and adults with chronic gastritis, symptoms were improved, inflammation decreased, and colonisation was reduced in response to oral antibody feeding; two additional studies were less conclusive.
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Leaky Gut and Irritable Bowel
Leaky gut syndrome has become as common an occurrence as the common cold, and it is caused by an inflamed and irritated bowel lining. This causes the intestinal lining to become more permeable than it should be. This increased permeability of the gut allows the absorption of larger molecules, which are normally broken down to smaller pieces and are utilised before passing into the body. All manner of disease, like viruses, bacteria, fungi, parasites, metals, candida, and toxic materials, are then able to invade the bloodstream and colonise just about anywhere in body tissue or organs causing disease processes to occur.
The inflammation of the gut can occur by quite a few things. Below is a list of some of these irritating agents: Any and all prescriptive corticosteroids; Alcohol and caffeine which irritate the gut wall (it includes diet and regular cokes, chocolate, coffee, cocoa); Contaminated foods, E. coli and other bacteria can develop due to poor food handling; Chemicals found in processed and fermented foods, for example, dyes and preservatives, wine, vinegar, soy sauce, tofu; A diet high in refined sugars and other carbohydrates for example, candy, cookies, sodas, processed foods and white bread; Foods contaminated by parasites; Antibiotic use, which causes an overgrowth of bacteria (yeast) in the gut due to the immune suppression that occurs.
The inflammation of the gut also damages the protective coating of the antibodies of the IgA family (immunoglobins) normally present in a healthy gut. The IgA's help our body to ward off infections, however, a leaky gut causes considerable damage to the immune system (IgA's) and makes us less resistant to viruses, bacteria's, parasites, toxic materials, metals and candida.
Another problem a leaky gut creates is a mineral deficiency. The carrier proteins which are needed for transporting specific minerals are damaged by the inflammatory processes. For example, a magnesium deficiency that is present in most Fibromyalgia patients. This patient can take incredibly high doses of magnesium, but if the carrier protein for this mineral is damaged, it will not get into the body where it is needed. This can also be true for some bone disorders. Even a zinc deficiency, which will effect hair loss and some eye disorders (macular degeneration). Copper deficiency can also occur this way which can lead to Osteoarthritis or even elevated blood cholesterol in some cases. This is true for any syndrome that could be connected to a mineral deficiency, or perhaps symptoms that don't seem to go away no matter what you do, consider the possibility of a leaky gut.
The inflammation in the gut also prevents absorption of vitamins and essential amino acids. Eventually nutritional deficiencies can lead to other complaints such as fatigue, headaches, memory loss, lack or concentration and irritability. Lower bowel gas, bloating and cramping are also among the symptoms that are associated with a leaky gut. Even unexplained weight gain is another symptom, which can be due to the deficiencies that are created by the leaky gut.
Another problem with leaky gut syndrome is that the toxins accumulating in the gut put an incredible burden on the liver. One of the liver's main jobs is to help keep the bowel clean for better nutrient absorption. When the bowel becomes overloaded with toxins the liver also becomes unnecessarily burdened. This decreases the liver's ability to work efficiently, which will then cause further disruption to the homeostasis of the body. Healing a leaky gut reduces the toxic load to our liver and body, and will greatly improve nutritional uptake.
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Leaky gut syndrome is almost always associated with auto-immune disease. Reversing the direction of a disease depends upon healing the lining of the gastrointestinal tract. Any other treatment is just symptom suppression.
Autoimmune diseases include arthritis, multiple sclerosis, asthma, chronic fatigue syndrome, alopecia, Addison's, Crohn's and Raynaud's diseases, fibromyalgia, lupus, thyroiditis, vasculitis and colitis.
These diseases result when damage is done by an immune system which cannot turn itself off. Because a leaky gut allows proteins to
be absorbed before they have had a chance to be completely broken down, the immune system does not recognise them. It sees these proteins as invaders and starts making antibodies. A protein from a food that was previously harmless now triggers a potentially serious allergic response that in turn damages body tissue. Suppressing the immune system is necessary to prevent the immune system from attacking the body itself.
For example, multiple sclerosis is an auto-immune disease that effects different parts of the nervous system through the destruction of myelin sheaths, the membrane that protects the body's nerves. This destruction produces any number of symptoms, including blurred vision, staggering gait, numbness, dizziness, slurred speech and even paralysis. The results can be devastating.
These types of diseases have been somewhat of a mystery to most healthcare professionals. Most recommended treatments simply provide minor relief of pain and other symptoms. The real issue lies in the discovery of how to stimulate or suppress the immune response.
Colostrum's suppressive action may help prevent this type of activity involved in autoimmune diseases. "Colostrum contains a special Proline-Rich-Polypeptide (PRP) that serves as a powerful regulator of the immune system. PRP has the same ability to regulate activity of the immune system as do the hormones of the thymus gland. It activates an underactive immune system, helping it move into action against disease-causing organisms." reports Staroscik, Poland 1983.
Dr. Zoltan Rona, agrees in a more recent report in The American Journal of Natural Medicine, March 1998: "PRP from colostrum can work as a regulatory substance of the thymus gland. It has been demonstrated to improve or eliminate symptoms of both allergies and auto-immune diseases (MS, rheumatoid arthritis, lupus, myasthenia gravis). PRP inhibits the overproduction of lymphocytes and T-cells and reduces the major symptoms of allergies and autoimmune disease."
The growth factors available in dairy colostrum can also repair the damage done by the disease. They work to stimulate tissue repair in the skin, the myelin sheath of the nerves and connective tissue throughout the body reducing pain and swelling and increasing mobility and freedom.
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Studies have revealed that colostrum is particularly effective in treating stomach damage that can occur after taking certain types of pain relieving medications, such as non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are drugs that are prescribed for sufferers of painful conditions such as rheumatism or arthritis.
The side effects of NSAIDs include gastric bleeding and damage to the stomach lining, which affects around two percent of the UK population and causes 2,000 to die each year.
During the trials, colostrum was found to be significantly beneficial in preventing damage to the stomach and intestine. As a result, the researchers have suggested that patients beginning a course of NSAIDs would benefit from taking a colostrum supplement.
Further trials are now underway to assess how colostrum could help patients with ulcerative colitis, a severe inflammatory condition of the large bowel. Initial tests have shown that at least one of the proteins present in colostrum can stimulate the repair process in this condition.
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Diabetes Type I, or juvenile onset diabetes, can be considered an autoimmune disease. Tests showed that a protein called GAD, found in cow's milk, can trigger an allergic response that damages the insulin-producing cells of the pancreas. Without insulin, the body is unable to use glucose for energy, so is forced to burn fat instead. The severe metabolic imbalance can lead to a dangerous condition called diabetic coma.
This type of diabetes seems to occur most often in children who did not receive colostrum at birth, or were not breast-fed for long. The immune factors in colostrum increases the tolerance for GAD, preventing the allergic response.
Once an individual develops Type I diabetes, the treatment options are very few. Generally, the condition is controlled with a combination of dietary restrictions, and daily insulin injections.
The body requires IGF-1 to metabolise fat for energy through the Krebs cycle. With aging, less IGF-1 is produced in the body. Inadequate levels are associated with an increased incidence of Type II diabetes and difficulty in losing weight despite a proper nutritional intake and adequate exercise.
A 1990 study suggested that colostrum supplementation would be a very beneficial treatment for diabetics, based on the fact that a key growth factor, IGF-1, can stimulate glucose utilisation. Researchers found that plasma levels of IGF-1 were lower in diabetic patients than in healthy individuals. After administrating IGF-1 to patients, the doctors noticed a two-fold increase in glucose transport to the muscles.
"IGF-1 stimulates glucose utilization. IGf-1 found in dairy colostrum (identical to human) can provide an effective acute treatment for Hyperglycemia. IGF-1 can be an effective alternative to insulin in stimulating transport in diabetic muscle. Plasma levels of IGF-1 in diabetic patients is lower than in non-diabetic groups. IGF-1 receptors are present in human muscles. IGF binding is 24% that of insulin. IGF-1 stimulated glucose transport two-fold. Did not stimulate transport in obese subjects." Extract from Dohm Elton, et al. Diabetes, Sept 30, 1990 pp 1028-32: IGF-1 Stimulated Glucose Transport.
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Wounds and Injury
The colostrum components, nucleotides, EGF, TGF and IGF-1, stimulate skin growth, cellular growth and repair by direct action on DNA and RNA. These growth factors facilitate the healing of tissues damaged by ulcers, trauma, burns, surgery or inflammatory disease. The tissues affected beneficially by colostrum's wound healing properties are skin, muscle, cartilage, bone and nerve cells.
Powdered colostrum can be applied topically to gingivitis, sensitive teeth, aphthous ulcers, cuts, abrasions and burns after they have been cleaned and disinfected.
neovite's amino acid profile includes Arginine. Arginine is glycogenic, which helps the body burn calories efficiently. It is considered crucial for optimal muscle growth and tissue repair. It stimulates the release of growth hormones and promotes wound healing and regeneration of the liver.
This is what the experts say about it:
"Growth factors in dairy colostrum were found to be very effective in promoting wound healing. Recommended for trauma and surgical healing. External and internal applications."
Drs. Sporn, et al., Science.
"IGF-1, found in colostrum, stimulates bone and muscle growth and nerve regeneration. Also, the topical administration to wounds resulted in more effective healing."
Drs. Skottner, Arrhenius-Nyberg, Kanje and Fryklund, Acta. Paediatric Scandinavia, Sweden.
"The failure of chronic wounds to heal is a major medical problem. Doctors suggest that growth factors are important in promoting wound healing. Accelerated healing is possible in the treatment of trauma and surgical wounds."
Drs. Bhora, et al., Journal Surgical Resource.
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Chemotherapy and HIV
The growth factors in colostrum help prevent 'wasting' (severe weight loss) in chemotherapy patients. Similarly, the AIDS infected body begins using muscle for energy. The increase in muscle mass with neovite helps for many sufferers. At the very least, colostrum will benefit the patient by prolonging and greatly improving the quality of life.
For patients with lowered immune systems, whether caused by therapy or by disease, neovite can help meet the challenge of opportunistic infections which result from a lowered immune system.
Colostral lactoferrin is one of the best ways to reduce viral levels in the body and it inhibits infection of certain body cells. A study from 1995, by researcher Martin C. Harmsen and associates from the Netherlands, indicates that the colostral immune factor lactoferrin is one of the best ways to reduce viral levels in the body.
Lactoferrin, along with many other immune factors in colostrum help to "jump start" and stimulate a weak immune system in newborn babies and has been proven to do the same thing for patients.
HIV positive patients who were treated with growth factors like IGF-1, were much less likely to develop full-blown AIDS than were other patients who received different treatments.
The following research studies agree in the use of colostrum for chemotherapy and AIDS patients:
"Dairy colostrum contains TGF-B which has an important suppressive anti-inflammatory effect on cytoxic substances. It inhibits cell growth of human Osteosarcoma cancer cells (75% inhibition). Mediator of fibrosis and angiogenesis (healing of heart muscle and blood vessels),
(Roberts et al., 1986), accelerates wound healing (Sporn et al., 1983) and bone formation (Centrella et al., 1987).
Drs. Tokuyama and Tokuyama; Cancer Research Institude, Kanazawa University Japan.
Researchers at San Francisco General Hospital gave preparations of dairy colostrum to people with AIDS who had chronic diarrhoea caused by Cryptosporidium parvum. They found that "consuming 40 grams of colostrum powder per day for 21 days reduced the diarrhoea." Greenberg PD, Cello JP. Treatment of severe diarrhoea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquired Immun Defic Synd Hum Retrovirol. 1996;13:348-354.
Researchers in Germany, also found that they were "able to reduce symptoms in people with HIV suffering from chronic diarrhoea, with preparations of dairy colostrum."
Rump JA, Arndt R, Arnold A, et al. Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from dairy colostrum. Clin Investig. 1992; 70:588-594.
Another research study at St. Vincent's Hospital and Medical Center in New York reports that "colostrum from immunised cows effectively improved symptoms in people with AIDS suffering from chronic diarrhoea."
Nord J, Ma P, DiJohn D, Tzipori S, Tacket CO. Treatment with dairy hyperimmune colostrum of cryptosporidial diarrhoea in AIDS patients. AIDS. 1990; 4:581-584.
In an open study "25 AIDS patients with cryptosporidiosis were treated with a daily oral dose of 10g of dairy colostrum for 10 day period. Complete remission was reported in 40% and a partial remission in 24% of patients. Treatment is judged to be effective."
Plettenberg, et al., 1993, Clinical Investigator, Vol. 71 p.p. 42-45.
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